ABSTRACT
In the past two decades, the prevention and control of endemic fluorosis in China has achieved remarkable results. In addition to brick-tea type of endemic fluorosis, drinking-water-type of endemic fluorosis and coal burning type of endemic fluorosis have been effectively controlled, and some areas have reached the elimination level. At present, the prevention and control of endemic fluorosis has changed from how to implement prevention and control measures to how to correct health damage, but three main problems must be solved. First, the characteristics and extent of multiple organ system damage caused by fluoride exposure need to be clarified. Second, the pathogenesis of fluorosis is still unclear. Third, the effective intervention methods of fluorosis are still limited. These problems cannot be fundamentally solved only by laboratory work, and there is an urgent need to provide more epidemiological evidence.